Miliary tuberculosis following infliximab therapy for Crohn disease : A case report and review of the literature
| Journal | Volume 69 - 2006 |
| Issue | Fasc.2 - Case reports |
| Author(s) | Ph. Stas, A. D'Hoore, G. Van Assche, K. Geboes, E. Steenkiste, F. Penninckx, P. Rutgeerts, S. Vermeire |
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| (1) Department of Gastroenterology, (2) Abdominal Surgery and (3) Pathology, University Hospital Gasthuisberg, Leuven, Belgium. |
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We present a case of miliary tuberculosis diagnosed 15 months after infliximab treatment despite negative screening for previous exposure to Mycobacteria on skin PPD and chest X-ray. This case shows that - although screening for TB with a skin PPD and a chest X-ray should be performed in all patients - this is not 100% effective and may be a problem in patients on concomitant immunosuppression. The clinical course of this patient further shows that in a patient treated with anti-TNF antibodies who's condition does not improve one should always be aware of the pos- sibility of a tuberculosis infection. Even though tuberculosis is usu- ally not rapidly fatal, the disease may show a fulminant course in immunocompromised patients. (Acta gastroenterol. belg., 2006, 69, 217-220). |
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© Acta Gastro-Enterologica Belgica. |
